Microbiome Imbalance Causes Acne
This balance is influenced by various factors. In the case of acne, your skin produces more sebum as part of the changes your body experiences during adolescence. The skin becomes inflamed in response to this sebum overproduction, causing your skin microbiome to be more prone to acne-causing bacteria. Andrea Szegedi of Hungary's University of Debrecen asserted in her study that acne should, therefore, be seen more as a natural, physiological occurrence rather than an "accidentally occurring disease."
Szegedi's conclusion that the imbalance in skin bacteria leads to acne agrees with the earlier findings of a team from UCLA's David Geffen School of Medicine. The group led by Dr. Huiying Li discovered that the bacterium Propionibacterium acnes (P. acnes) is found in people with and without acne, but they found out that adults with acne had high levels of genes linked to the toxin-producing bacteria that promoted inflammation. Meanwhile, the skin of acne-free adults contained more genes that helped protect the skin from being colonized by harmful bacteria. Li suggests that treatments focusing on "modulating" skin microbiota are better than using antibiotics that can kill bacteria beneficial to the skin.